Does Anesthesia Cause Postoperative Cognitive Decline?

Does Anesthesia Cause Postoperative Cognitive Decline?

Does cognitive reserve shape cognitive decline?

OBJECTIVE Cognitive reserve is associated with a lower risk of dementia, but the extent to which it shapes cognitive aging trajectories remains unclear. Our objective is to examine the impact of 3 markers of reserve from different points in the life course on cognitive function and decline in late adulthood. METHODS Data are from 5,234 men and 2,220 women, mean age 56 years (standard deviatio...

Postoperative cognitive decline: where art tau?

T AU is an axonal microtubule-associated protein whose best known function is to bind and stabilize microtubules and promote their polymerization. Tau, a variously sized protein, has a number of repeated domains that bind tubulin and a number of phosphorylation sites that modulate its affinity for tubulin. In general, phosphorylation through a number of kinases decreases tau affinity to microtu...

Is postoperative cognitive decline clinically relevant?

To the Editor: We applaud Avidan et al. in their assessment of the general relationship between postoperative cognitive dysfunction (POCD) and dementing illness. We have a number of questions and concerns, and we hope the authors might address them. As noted by the authors, the report revisits the question of whether geriatric patients who undergo surgery have a more rapid decline into dementia...

The neuroinflammatory response of postoperative cognitive decline.

BACKGROUND Aseptic surgical trauma provokes a homeostatic neuroinflammatory response to promote healing and protect the organism from further injury. When this response is dysregulated, harmful consequences can follow, including postoperative cognitive decline. SOURCES OF DATA We performed a comprehensive search on PubMed related to postoperative cognitive dysfunction (POCD). AREAS OF AGREE...